What is the initial chemical precursor of DNA strand breaks generated by direct-type effects?
Article Abstract:
The study tests the hypothesis that the majority of DNA strand breaks produced by direct-type effects are due to sugar free radical precursors and that these radicals are produced by direct ionization of the sugar-phosphate backbone or by hole transfer to the sugar from tightly bound water. The approach entails determining the free radical dose response of well-defined crystalline DNA samples irradiated at 4 K.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2004
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Diffusion approach to long distance charge migration in DNA: time-dependent and steady state analytical solutions for the product yields.
Article Abstract:
An analytical solution for unbiased charge transfer through regular DNA sequence via a hopping mechanism for time-dependent and steady state problems is listed. The biggest advantage of this approach is the capability of describing analytically time-resolved and steady state kinetics of charge migration in DNA.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
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