DNA polymerase gamma in mitochondrial DNA replication and repair

Article Abstract:

The DNA polymerase gamma (pol gamma), the only DNA polymerase found in animal cell mitochondria, is responsible for DNA synthesis in all replication, recombination and repair involving mitochondrial DNA (mt DNA). Motochondria trancription factor (mt TFA) protein and pol gamma bind regulatory sequences and replication factors in the D-loop during replication and base excision repair of damaged DNA bases, involving pol gamma, is the major mt DNA repair mechanism.

Analysis, DNA replication

---

Structure and mechanism of DNA polymerase beta

Article Abstract:

The DNA polymerase beta (pol beta), the simplest naturally occurring cellular DNA polymerase, is a multidomain protein whose tightly folded domains and subdomains, linked by short solvent-exposed regions, are involved in nucleotidyl transferase and lyase reaction mechanisms. Steady-state kinetic analyses indicate that pol beta follows an ordered addition of substrates and multiple conformations of the enzyme and the substrates are possible.

Transferases, Structure

---

Similar abstracts:

• Abstracts: Molecular mechanisms and mammalian global genome nucleotide excision repair. Prokaryotic nucleotide excision repair: The UvrABC system
• Abstracts: DNA repair in plants. Roles of DNA polymerase V and RecA protein in SOS damage-induced mutation

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.