Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis

Article Abstract:

The structure, mode of action, and resistance to the streptogramin and oxazolidinone antibiotics- two distinct classes of antibiotics that have recently brought to market for treatment of bacterial infections- are described and also, a brief discussion of some new and old classes of antibiotics that block translation is presented. Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus.

Protein synthesis, Protein biosynthesis

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Rifamycin-mode of action, resistance, and biosynthesis

Article Abstract:

Rifamycin belongs to the family of ansamycin antibiotics and it displays a broad spectrum of antibiotic activity against Gram-positive and, to a lesser extent, Gram-negative bacteria and different prokaryotic organisms show different degrees of susceptibility to inhibition by rifamycins. The inhibition of DNA-dependent RNA polymerase seems to be the common mechanism for all antibacterially active rifamycins.ll

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Bacterial topoisomerase inhibitors: Quinolone and pyridone antibacterial agents

Article Abstract:

The quinolone anti-infective agents are of wholly synthetic origin and a wide variety of clinical indications are approved for quinolones including many infections commonly encountered in community-like gastrointestinal infections, respiratory infections and gynecologic infections. The availability of nalidixic acid was instrumental in assisting the discovery of the targeted bacterial type II topoisomerases.

Quinolones

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