NMR characterization of the dynamics of biomacromolecules
Article Abstract:
The important usages of spin relaxation methods for investigating conformational dynamic processes in proteins and nucleic acids are explained. The experimental techniques used for measuring spin relaxation rate constants are reviewed.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2004
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Theory and applications of NMR based screening in pharmaceutical research
Article Abstract:
The theoretical as well as the practical aspects of Nuclear Magnetic Resonance (NMR) based screening methods are explained. Examples of the way these NMR methods are used to generate new chemical ligands for drug targets are presented.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2004
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- Abstracts: Unfolded proteins and protein folding studied by NMR. NMR studies of modular protein structures and their interactions
- Abstracts: Dynamics of water in biological recognition. Ultrafast excited-state dynamics in nucleic acids. Toward an integrated model of protein - DNA recognition as inferred from NMR studies on the Lac repressor system