A new uncoupling protein: a potential component of the human body weight regulation system

Article Abstract:

Two laboratories have recently reported findings related to an uncoupling protein homologue (UCPH) that may participate in body weight regulation in humans. UCPH appears to be similar to the known uncoupling protein (UCP) found in the brown adipose tissue of rodents, a mitochondrial protein that uncouples respiration from oxidative phosphorylation and adenosine triphosphate formation. Results reported from the laboratories of Tartaglia and Warden detail the tissue distribution of UCPH and how the protein was isolated and sequenced.

Physiological aspects, Phosphorylation, Body weight, Brown adipose tissue

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Retinol transport and metabolism in transthyretin-"knockout" mice

Article Abstract:

An experiment wherein mice were made deficient in transthyretin (TTR) through targeted mutagenesis showed that these TTR mice remained fertile and in good health despite very low circulating levels of plasma retinol and retinol-binding protein (RBP). TTR is the protein that usually transports RBP-plasma retinol complex. RBP levels in the liver were extremely high, thus indicating that a deficiency in TTR may inhibit secretion of RBP-retinol from liver.

Usage, Proteins, Mice as laboratory animals, House mouse, Retinoids

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A transporter specific for retinol in the brush border of rat small intestine

Article Abstract:

Assessment of the uptake of retenoids into gut sheets of rat small intestine revealed a distinct transporter in the intestinal brush border for all-trans- and 3-dehydroretinol, which constitute a procedure of carrier-facilitated diffusion. The remaining 9- and 13-cis and retinal retinoids are taken up at slower rates by unresisting diffusion.

Analysis, Metabolic regulation, Rats, Intestine, Small, Small intestine

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