Insulin insensitivity is rapidly reversed in rats by reducing dietary fat from 40 to 30% of energy

Article Abstract:

The effect of dietary fat reduction on the body composition and insulin sensitivity was investigated and the use of fat-mimetic carbohydrate against plain carbohydrate was evaluated. Three groups of rats were fed different amounts of fat, after which, morphologic and biochemical analyses were done. Results showed that a high fat diet caused obesity, insulin insensitivity and hyperinsulinemia. A modest fat intake reduction of 10% readily reversed the effects although cellular response to insulin was not constant. The use of fat-mimetic carbohydrates did not have any observed benefits in rats.

Testing, Dietary fat, Insulin resistance, Fat substitutes

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Total parenteral nutrition with short- and long-chain triglycerides: triacetin improves nitrogen balance in rats

Article Abstract:

The use of triacetin as a component of total parenteral nutrition in rat metabolism was investigated. Total parenteral nutrition of different lipid compositions was delivered via catheter for seven days and metabolic products were calculated. Results showed that short chain triglycerides like triacetin produced positive nitrogen balance with no adverse effects regardless of protein ingestion. This shows thay short chain fatty acids may be the suitable for parenteral nutrition because it is tolerated well and readily provides metabolic substrates without protein expenditure.

Health aspects, Parenteral feeding, Parenteral nutrition, Fat metabolism, Triglycerides

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Dietary beta-carotene reduces serum lipid concentrations in spontaneously hypertensive rats fed a vitamin A-fortified and cholesterol-enriched diet

Article Abstract:

The antihyperlipidemic effects of beta-carotene in rats were investigated. Spontaneously hypertensive rats were used because these become hyperlipidemic with age, and thus make measurement easier. Serum levels of lipoprotein were measured after a 44-day diet enriched with vitamin A, cholestereol and varying amounts of beta-carotene. Results showed that dietary beta-carotene decreased total serum cholesterol, triacylglycerol and lipoprotein levels. However, the hypocholesterolemic effect of beta carotene in humans still has to be studied.

Blood lipids, Beta carotene

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