Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake

Article Abstract:

Sterol regulatory element binding proteins (SREBPs), which are newly discovered, are controllers of lipid synthesis and cellular uptake in mammalian cells. When cellular cholesterol levels go down, genes that encode the low-density lipoprotein receptor and multiple enzymes in the cholesterol and fatty acid biosynthetic pathways are transcribed in large amounts, but transcription is repressed when sterols build up in the cell. The mechanism of the regulation has not been well understood, but answers are emerging.

United States, Genetic aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), Protein binding, Cellular control mechanisms, Cell regulation, Lipids, Cell receptors, Mammals, Lipid synthesis

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Comparable efficacy of hydrogenated versus nonhydrogenated plant sterol esters on circulating cholesterol levels in humans

Article Abstract:

Research has determined that plant sterol esters are effective in maintaining healthful cholesterol levels. Studies using margarine containing sitostanol-ester and soybean oil sterol-ester showed that both were equally effective in decreasing low-density lipoprotein and blood total cholesterol levels. Neither of the two esters affected high-density lipoprotein cholesterol levels.

Cholesterol, Margarine

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Differential effects of individual trans fatty acid isomers on lipoprotein assembly and metabolism

Article Abstract:

Some trans fatty acid isomers influence the secretion of intestinal lipoproteins. This suggests a mechanism sensitive to geometric configuration as well as fatty acid chain length and double bond position.

Lipoproteins, Trans fatty acids

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