Using animals to assess bioavailability of minerals: implications for human nutrition

Article Abstract:

Several factors have to be considered in comparing bioavailability studies of minerals in animal models and human nutrition studies. Dietary composition, dosing regimens, doses and forms of nutrients administered, and measures of bioavailability should be carefully considered to make such comparisons or practical applications valid. For instance, although mineral metabolism in humans and rats are generally consistent, their differences in food intake as well as metabolism are quite marked. Animal models are important in toxicology as well as in research involving chronic administration of substances, which are not usually feasible in human nutrition studies.

Analysis, Nutritional aspects, Minerals (Nutrients), Animal nutrition, Animal models in research, Animal research models, Minerals in human nutrition, Minerals in animal nutrition

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Dietary protein, as egg albumen: effects on bone composition, zinc bioavailability and zinc requirements of rats, assessed by a modified broken-line model

Article Abstract:

The effect of dietary protein on zinc requirement and zinc bone deposition in growing rats was investigated. It was shown that high levels of dietary protein increased the dietary requirement for zinc, reduced feed intake and growth in zinc-deficient rats, and increased zinc deposition on bones in rats with adequate dietary zinc. High protein diets also decreased the organic matrix of bone while increasing zinc deposition. This indicates that excess dietary protein results in a metabolic disorder rather than an enhancement of the zinc's bioavailability.

Physiological aspects, High-protein diet, High protein diet, Zinc metabolism

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Bioavailability of vitamin B-6 in pregnant rats

Article Abstract:

The influence of pregnancy on the bioavailability of vitamin B-6 was analyzed by oral administration of pyridoxine to pregnant and non-pregnant rats. Plasma pyridoxal 5 phosphate levels (PLP) were found to be less in pregnant than in non-pregnant rats despite increased intake. Oral pyridoxine was almost totally absorbed in the gut and hepatic uptake was constant. Alkaline phosphatase activity does not affect PLP levels. PLP levels are decreased in pregnancy because of associated increase in erythrocyte levels available for binding and fetal consumption.

Health aspects, Food and nutrition, Pregnancy, Rats, Vitamin B6, Pyridoxine

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