A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty

Article Abstract:

Hirudin may be no more effective than heparin in improving survival of patients who have had angioplasty, but hirudin may be more effective in preventing immediate blood vessel blockage. Following coronary angioplasty, 382 patients received intravenous heparin for one day, 381 received intravenous hirudin for one day, and 378 received intravenous hirudin for one day, followed by subcutaneous hirudin for three days. Researchers analyzed the occurrence of cardiac events such as heart attack, death, bypass surgery, and chest pain. During seven months of follow-up, the rates of these events were approximately equal in each treatment group. Survival rate without an event was also the same in each group. However, hirudin was more effective in preventing events in the 96 hours immediately following angioplasty. Bleeding complications were similar in each group.

Complications and side effects, Heparin, Angioplasty, Antithrombins, Hirudin

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Intracoronary radiotherapy for restenosis

Article Abstract:

More research is needed on intracoronary radiotherapy before it can be widely used to prevent coronary arteries from becoming blocked after angioplasty. This technique involves putting a small radioactive source inside the artery. Two studies published in 2001 showed that it can reduce the rate of repeat blockage but may increase the risk of blood clot formation.

Editorial

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Endoluminal beta-radiation therapy for the prevention of coronary restenosis after balloon angioplasty

Article Abstract:

Beta radiation can prevent coronary arteries from becoming blocked again after angioplasty, according to a study of 181 patients. The beta radiation is delivered via a small radioactive source on a wire that is placed inside the artery.

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