A computer-controlled, continuously circulating, hot irrigating system for endometrial ablation

Article Abstract:

A thermal irrigation system that is hooked up to a computer can provide continuous heated saline solution to destroy endometrial tissue in women with abnormal uterine bleeding. Researchers tested this system on five female sheep and on 32 freshly removed human uteruses. The temperature ranged from 65 to 90 deg Centigrade (C.) and the irrigation lasted 15 to 20 minutes. Sensors in the uterus measured the temperature of the endometrial tissue, which ranged from 35 to 49 deg C. Uterine tissue samples examined microscopically after the treatment showed destructive changes in the endometrium, but the endometrium still appeared viable. Destruction of the abnormal endometrium was greater at temperatures greater than 80 deg C. This technique could reduce the number of hysterectomies performed for abnormal uterine bleeding. However, it is important to cauterize the myometrium, or middle layer of the uterus, because this is where bleeding starts.

Evaluation, Uterine bleeding, Uterine hemorrhage, Cautery, Irrigation (Medicine)

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Strategies to reduce the incidence of endometrial cancer in postmenopausal women

Article Abstract:

Detection of endometrial cancers may be enhanced by the progestogen challenge test before hormone replacement therapy and annually in postmenopausal women not taking estrogen. Progestogens are given for 13 days. Bleeding after discontinuation often indicates an abnormal uterine lining, and should be investigated with an endometrial biopsy, as should breakthrough bleeding during hormone replacement therapy. No cancers have been reported with sequential hormone replacement therapy, while cyclic combined therapy may decrease risks associated with continuous combined therapy.

Prevention, Endometrial cancer, Progestational hormones

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Association of asymptomatic bacterial vaginosis with endometrial microbial colonization and plasma cell endometritis in nonpregnant women

Article Abstract:

A study examines if nonpregnant women diagnosed with asymptomatic bacterial vaginosis (BV) are in any way associated with an increased risk of endometrial microbial colonization or plasma cell endometritis. The result shows that women with BV have higher frequency of positive endometrial cultures as compared with women without BV.

Diagnosis, Vaginosis, Endometritis, Bacterial vaginosis

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