A controlled trial of buprenorphine treatment for opioid dependence

Article Abstract:

Buprenorphine may be as effective as methadone in treating narcotic dependence. Buprenorphine is a morphine-like drug similar to methadone but with fewer side effects. Of 162 narcotic addicts in a Baltimore, MD treatment center, 53 were given eight milligrams (mg) of buprenorphine a day, 55 were given 20 mg of methadone a day and 54 were given 60 mg of methadone a day. At the end of 17 weeks, they entered an eight-week detoxification phase, during which time their dosages were gradually reduced. Urine samples were periodically tested for narcotics. Thirty percent of the addicts on buprenorphine completed the 25-week treatment program, compared to 20% of those taking 60 mg of methadone and six percent of those taking 20 mg of methadone. A greater percentage of addicts in the buprenorphine group had negative urine drug tests, compared with the groups taking methadone. The higher dose of methadone was more effective than the lower dose.

Care and treatment, Drug abuse treatment, Methadone maintenance

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Counseling plus buprenorphine-naloxone maintenance therapy for opioid dependence

Article Abstract:

A study was conducted to establish the optimal level of counseling and frequency for buprenorphine-naloxone treatment for opioid dependence. For patients receiving buprenorphine-naloxone in primary care for opioid dependence, no difference in efficacy was recorded between brief weekly counseling and once-weekly medication dispensing with that of extended weekly counseling and thrice-weekly dispensing. It was concluded that strategies should be improved for buprenorphine-naloxone adherence.

United States, Specialty outpatient clinics, not elsewhere classified, Outpatient Mental Health and Substance Abuse Centers, Alcohol & Drug Abuse Programs, Substance abuse, Dosage and administration, Substance abuse treatment

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Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone

Article Abstract:

The drug buprenorphine alone or in combination with naloxone appears to be effective for treating heroin addiction in a primary care setting, according to two studies of 326 and 461 heroin addicts. The drugs were more effective than a placebo, or inactive substance. Over a one-year period, up to 67% of the addicts' urine samples tested negative for heroin. They also said the drug reduced their craving for heroin.

Heroin habit

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