A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families
Article Abstract:
A mutation in the presenilin 1 gene was found in eight out of 19 Caribbean Hispanic families with a family history of Alzheimer's disease that occurred before the age of 55. The families were not related to each other, indicating that they all had a common ancestor. The rate of Alzheimer's disease is higher in Caribbean Hispanics than in non-Hispanic whites.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
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Apolipoprotein E epsilon4 and the risk of dementia with stroke: a population-based investigation
Article Abstract:
The apolipoprotein E (APOE) epsilon4 gene appears to increase the risk of developing dementia associated with atherosclerosis and strokes. Researchers used genetic testing for the APOE epsilon4 gene in 187 people with dementia and stroke and 507 healthy volunteers (the control group). One copy of the APOE epsilon4 gene increased the risk of dementia with stroke 2-fold and two copies of the gene increased the risk by a factor of 7. The risks were especially great in African Americans and Hispanics. The APOE epsilon4 gene has also been implicated in Alzheimer's disease.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1997
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The APOE-epsilon4 allele and the risk of Alzheimer disease among African American, whites, and Hispanics
Article Abstract:
The apolipoprotein E (APOE) epsilon4 gene does not appear to be a risk factor for Alzheimer's disease in African Americans and Hispanic Americans. Researchers tested 1,079 elderly patients in a multi-ethnic neighborhood for the gene and followed them for over five years. While the presence of the gene increased the risk of Alzheimer's disease in the whites, this was not true in the blacks and Hispanics. However, blacks and Hispanics who did not have the gene had a higher risk of Alzheimer's disease than whites. Other genes may be responsible for the increased risk in these ethnic groups.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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