A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection
Article Abstract:
Patients receiving 500 mg. didanosine had a slower progression of HIV disease and fewer deaths within a study period than did those receiving zidovudine (AZT) or 750 mg. of didanosine. These results may occur from the change in medication or from other unknown factors and suggest that didanosine may have wider use than only for patients who cannot tolerate AZT. The effectiveness of didanosine was not related to the length of time patients had previously taken AZT. The lower rate of pneumonia and HIV related problems occurred in patients with AIDS-related complex and those with no symptoms. There were different rates of various side effects for each drug. Both the number of CD4 cells and p24 antigen levels were higher in both groups taking didanosine. Patients who voluntarily withdrew from the study had lower initial CD4 counts and pretreatment AIDS diagnosis. They discontinued the medication to receive other antiviral agents. Mortality rates did not differ among the groups.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1992
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Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection
Article Abstract:
Doctors should prescribe zidovudine, lamivudine, and efavirenz for all newly diagnosed HIV patients, according to a study of 620 patients. This combination was more effective than other combinations for the initial treatment because it suppressed the virus more quickly and was effective for a longer period of time.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
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