Activated protein C resistance and adverse pregnancy outcome

Article Abstract:

There appears to be a correlation between a genetically transmitted clotting disorder called activated C protein resistance and severe complications with pregnancy. Researchers have studied a cluster of seven patients with histories of multiple miscarriages, infant death within the womb, or preeclampsia, all of whom had low activated C protein ratios. All patients carried at least one copy of a genetic mutation called the Leiden mutation. Two patients had immediate family members who died of blood clots in the heart or brain. One patient had experienced previous blood clots in her legs.

Risk factors, Thromboembolism, Pregnancy, Complications of, Pregnancy complications, Protein C

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Aspirin pretreatment potentiates hyperthermia-induced teratogenesis in the mouse

Article Abstract:

Aspirin may increase the rate of birth defects caused by elevation of body temperature. High body temperature during pregnancy, as might result from fever, immersion in a hot tub, or strenuous exercise, can cause fetal deformities. Researchers evaluated the effect of hyperthermia by immersing mice in warm water, then examining their fetuses ten days later. The rate of skeletal defects after exposure to 108 degrees F. was 20%. In mice given aspirin before hyperthermia, the rate of skeletal deformities was 56%. Aspirin inhibits prostaglandins, which may protect cells against high heat.

Health aspects, Abnormalities, Birth defects, Aspirin, Fever, Hyperthermia, Spinal cord

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Comparison of transvaginal sonography with digital examination and transabdominal sonography for the determination of fetal head position in the second stage of labor

Article Abstract:

The accuracy and time requirements of transvaginal scans (TVS) in the second stage of labor are examined. TVS is found to be the shortest and most accurate method for determining fetal head position in the second stage of labor.

United States, Evaluation, Comparative analysis, Pregnancy, Pregnancy diagnosis, Abdominal ultrasonography

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