Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogenetic hematopoietic stem cell transplantation
Article Abstract:
A study was conducted infusing cultured mouse hematopoietic stem cells (HSCs), in vitro on OP9 mouse stromal cells expressing the Notch-1 ligand Delta-like-1 (OP9-DL1) together with T-cell-depleted mouse bone marrow or purified HSCs into lethally irradiated allogeneic recepients to determine their effect on T-cell reconstitution after transplantation. Results indicated that the adoptive transfer of OP9-DL1-derived T-cell precursors enhanced T-cell reconstitution, after transplantation, resulting in graft-versus-tumor (GVT) activity without graft-versus-host disease (GVHD).
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Protecting the host naturally
Article Abstract:
Hematopoietic cell transplantation (HCT) is the only therapy for a range of hematologic malignancies but still, improvements in the procedure of HCT people suffer from graft-versus-host disease (GVHD). Hence, a new regimen is introduced that achieves engraftment with a remarkably low incidence of GVHD by reduced toxicity of such preparative regimens.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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JAKing up immunosuppression
Article Abstract:
The effect of a new immunosuppressive agent on the cytoplasmic tyrosine kinase Janus kinase-3 (JAK-3), developed by Changelian et al., is analyzed. The probable potential toxicities and side effects are commented.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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