Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
Article Abstract:
A study demonstrates through a postmortem tissue-stimulation approach that there is marked increase in the neuregulin 1(NRG1)-induced activation of erbB4 in the prefrontal cortex in schizophrenia. NRG1 stimulation suppresses N-methyl-D-aspartate (NMDA) receptor activation in the human prefrontal cortex and the findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Jeffrey Michael Isner
Article Abstract:
Jeffrey Michael Isner has died at the age of 53 of a heart attack. During his short carrier his contributions in the field of cardiology and developmental biology include VEGF gene therapy research, isolation of putative endothelial cells for angiogenesis and creation of the internationally recognized cardiovascular research program.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling
Article Abstract:
Research focuses on improving the efficacy of tissue-plasminogen activator (t-PA) to treat thrombo-embolic stroke, as adverse effects have been noted in some patients. Topics discussed include the physiological aspects of neurodegeneration, and the effect of t-PA on the functioning of the N-methyl-D-aspartate receptor.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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