Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming

Article Abstract:

Altered peptide ligands have been shown to narrow the repertoire of cellular immune responses. They do this by interfering with T-cell priming. Mutual interference with the priming of human T-cell responses by a pair of naturally occurring variants of a malaria cytotoxic T-cell epitope was detected and interference with priming in vivo for a murine malaria T-cell epitope exists.

United Kingdom, Physiological aspects, Peptides, Cytochemistry, Cellular immunity

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Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis

Article Abstract:

Tolerance and costimulatory molecule blockade experiments indicate that spread epitope-specific T cells are the major functional cause of disease progression. The results also reveal that naive T cells enter the inflamed CNS and are activated by local antigen-presenting cells (APCs) to initiate epitope spreading.

Science & research, Research, Genetic aspects, Multiple sclerosis, Antigenic determinants

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