Quinolone-based antibacterial chemoprophylaxis in neutropenic patients: effect of augmented gram-positive activity on infectious morbidity

Article Abstract:

The addition of the drug rifampin to quinolone antibiotic treatment appears to reduce the incidence of streptococcal infections in patients with low white blood cell counts. Doctors randomly assigned 111 patients with low white blood cell counts to take either norfloxacin, ofloxacin, or ofloxacin plus rifampin. Fewer patients taking ofloxacin plus rifampin developed infections (9%) than those taking ofloxacin alone (24%) or norfloxacin alone (47%). There was no significant difference in the number of fever episodes among the three treatment groups.

Health aspects, Streptococcal infections, Prevention, Quinolone antibacterial agents, Fluoroquinolones, Neutropenia

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A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy

Article Abstract:

The analgesic activity of 2 doses of parecoxib sodium, ketorolac and morphine with placebo after gynecologic surgery requiring laparotomy was compared. It was found that parecoxib sodium was an effective analgesic in the management of acute postoperative pain and laparotomy surgery.

United States, Drug therapy, Dosage and administration, Abdomen, Laparotomy, Gynecology, Operative, Gynecological surgery, Pain, Postoperative, Postoperative pain, Ketorolac

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