Antiretroviral-associated toxicity among HIV-1-seropositive pregnant women in Mozambique receiving nevirapine-based regimens
Article Abstract:
A prospective cohort study is used to assess toxicities associated with highly active antiretroviral therapy (HAART) among HIV-1-infected Mozambican pregnant women treated with nevirapine-based regimens. The results have shown that severe hepatoxicity from nevirapine-containing HAART in this cohort of pregnant women was more common at higher CD4 counts, proposing that laboratory monitoring is necessary when administering nevirapine-containing regimens to pregnant women with CD4 counts greater than or equal to 250 cells/[micro]L.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2007
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Enzyme inducers reduce elimination half-life after a single dose of nevirapine in healthy women
Article Abstract:
A pilot study's primary objective was investigating the effect of intervention strategies with a number of agents on the elimination half-life of nevirapine (NVP). Appropriately powered safety and feasibility end point studies are required to be conducted before these interventions can be tested in the setting of single-dose NVP (SD-NVP) for the prevention of mother-to-child transmission (MTCT) (PMTCT) of HIV for reducing the development of NVP resistance.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
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Early response to highly active antiretroviral therapy in HIV-1-infected Kenyan children
Article Abstract:
The early response to World Health Organization (WHO) that had recommended nonnucleoside reverse transcriptase inhibitor (NNRT1) containing highly active antiretroviral therapy (HAART) in HIV-1-infected Kenyan children unexposed to nevirapine is described. It is observed that there is good early clinical and virologic response to NNRTI-based HAART.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
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