Apparent decreased risk of invasive bacterial disease after heterologous childhood immunization

Article Abstract:

A number of studies have reported an increased incidence (number of new cases) of invasive bacterial disease in children soon after they have received various vaccines. This study assessed whether there was an increased risk for invasive bacterial disease in children soon after they were given the diphtheria, tetanus, and pertussis (DPT) vaccine, the measles, mumps, and rubella (MMR) vaccine, or the oral poliovirus (OPV) vaccine. The medical and vaccination records of 223 children, aged one month to two years, who had acquired invasive bacterial disease were examined. Two control subjects, matched for similarities to each case, were randomly chosen, and telephone interviews were conducted for both the children who had bacterial disease and the controls. Final data was obtained from 202 of the cases and 414 controls. Results showed that the controls were more likely to have been immunized prior to the onset of illness than the children who became seriously ill. The risk for developing disease soon after vaccination with DPT or OPV was lower by a factor of 0.07 to 0.44. When other differences were examined, it was found that the risk for invasive bacterial disease was higher among children in day-care; their risk was 2.4 times greater than that of children who were not in day-care. In addition, the risk of invasive bacterial disease was four times greater in children whose records did not show routine well-care visits, compared with those who had such visits. When these factors were assessed, the protective effect of recent immunization was reduced to insignificant levels. The results indicate that recent vaccination does not increase children's chances for developing invasive bacterial disease, but, in fact, may provide a slight protective effect. (Consumer Summary produced by Reliance Medical Information, Inc.)

Health aspects, Complications and side effects, Risk factors, Vaccination of children, Vaccination, Bacterial infections, Vaccines

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The immunization status of children with spina bifida

Article Abstract:

Children with chronic diseases may receive inadequate or inappropriate primary care although given complex care services. One indicator of unsatisfactory primary care is a delayed or incomplete immunization program. Children with chronic illnesses may be vulnerable to a worsening of their chronic condition should they acquire a disease that is vaccine-preventable. The clinical, social, demographic and provider factors affecting the timeliness of immunization among chronically ill children is not adequately understood. Even with the use of relatively lenient criteria for immunization delay and the exclusion of children with incomplete immunization, it has been found that considerable numbers of children with spina bifida are underimmunized. Families must be educated about the importance of immunizations, especially regarding children with chronic illness. The results of a study of 120 children from 4 months to 18 years of age are presented.

Care and treatment, Evaluation, Physiological aspects, Immunization of children, Immunization, Chronically ill children, Spina bifida

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