Brief report: lymphoma with recurrent cycles of spontaneous remission and relapse - possible role of apoptosis
Article Abstract:
Recurrent cycles of spontaneous remission and relapse of lymphoma may be caused by apoptosis, or programmed cell death. The case of a 61-year-old man with mantle-cell lymphoma showed 15 cycles of acute illness alternating with spontaneous remission over a period of 50 months. The acute B-cell clone regressed during spontaneous remissions, while the other B-cell clone remained stable. The proliferation and death of the acute clone cells may control the occurrence of disease cycles. No molecular changes were seen in bcl-2 and p53 genes, which are known to control apoptosis. The activity of certain autoantibodies may cause the repetition of acute phase regression. The leukemic phases may be initiated during the acute phase and be induced by an activation signal to the neoplastic (tumor) cells. Such a signal might be provided by a chronic viral infection. Activation of lymphoma cells may enable their escape from a regulatory mechanism and cause the leukemic phase.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1995
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The influence of margin width on local control of ductal carcinoma in situ of the breast
Article Abstract:
Postoperative radiation treatment may not be needed in women with ductal carcinoma in situ if the margin width is at least one millimeter or more. Ductal carcinoma in situ is a form of breast cancer that can be treated surgically. When surgeons remove the tumor, they also remove tissue that extends beyond the tumor. The amount this tissue extends beyond the tumor is called the margin width. In a study of 469 women who had breast-conserving surgery, recurrence rates were similar in women who did or did not receive postoperative radiation treatment, but only if the margin width was at least one millimeter.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
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