Assessment of the European classification criteria for Sjogren's syndrome in a series of clinically defined cases: results of a prospective multicentre study

Article Abstract:

A classification system proposed by the European Community seems to accurately identify patients with primary and secondary Sjogren's syndrome (SS). Researchers evaluated the usefulness of the six criteria in the system by testing 157 patients with confirmed SS and 121 patients with SS-like symptoms (controls) against these proposed benchmarks. The system accurately identified 97.5% of the patients with primary SS and 94.2% of the controls using four out of six items as confirmation of disease identification. The accuracy was similar for patients with secondary SS. With the elimination of the salivary gland testing, the system accurately identified only 83.7% of the patients with primary SS.

Diagnosis, Sjogren's syndrome

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T cell derived cytokines in psoriatic arthritis synovial fluids

Article Abstract:

Activated T cells may be associated with the inflammatory joint disease psoriatic arthritis (PsA). Proinflammatory and antiinflammatory cytokines, powerful substances secreted by T-type white blood cells, are associated with autoimmune arthritic conditions. Researchers compared T cell-derived cytokines in the synovial fluid of patients with PsA, rheumatoid arthritis (RA), and osteoarthritis (OA). Tumor necrosis factor, interferon alpha, interleukin 4 and interleukin 10 were less common, and present in lower concentrations, in PsA, compared to RA. These cytokines were not associated with OA.

Austria, Physiological aspects, Interferon gamma, Cytokines, Tumor necrosis factor, Interleukin-4, Interleukin-10, Psoriatic arthritis

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Bone mineral density and biochemical parameters of bone metabolism in female patients with systemic lupus erythematosus

Article Abstract:

Many patients with systemic lupus erythematosus also have osteoporosis, according to a study of 30 women with lupus. More than one-third had osteoporosis. This was due in part to decreased bone formation.

Causes of, Complications and side effects, Systemic lupus erythematosus, Osteoporosis

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