Association of polymorphism within the promoter of the tumor necrosis factor alpha gene with increased risk of preterm premature rupture of the fetal membranes

Article Abstract:

The TNFA*2 promoter gene may be linked to a predisposition to premature rupture of membranes in pregnant women. Premature rupture of membranes usually leads to premature birth. Researchers used the polymerase chain reaction to determine which tumor necrosis factor alpha promoter gene 220 pregnant women had. Those who had the rarer form called TNFA*2 were more likely to have premature rupture of membranes compared to those who had TNFA*1. Tumor necrosis factor alpha is produced by the body during infections. Many doctors believe premature rupture of membranes is caused by an infection.

Genetic aspects, Premature rupture of membranes, Premature rupture of the membrane

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A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth

Article Abstract:

A study was conducted to assess whether the presence of symptomatic bacterial vaginosis amplifies the risk of spontaneous preterm birth with a susceptible tumor necrosis factor (TNF) alpha gene. Preliminary evidence reveals that an interaction between genetic susceptibilities (i.e., TNF-2 carriers) and environmental factors (i.e., bacterial vaginosis) possesses an increased risk of spontaneous preterm birth.

Infants (Premature), Premature infants, Vaginosis, Tumour necrosis factor, Bacterial vaginosis

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Abnormal multiple marker screens are associated with adverse perinatal outcomes in cases of intrauterine growth restriction

Article Abstract:

Studies to determine if abnormal multiple marker screens (MMS) are associated with adverse perinatal outcomes in intrauterine growth restriction (IUG-R) pregnancies were conducted. In cases of intrauterine growth restriction (IUGR), an elevated human chorionic gonadotropin (HCG) and low unconjugated estriol (uE3) were associated with adverse perinatal outcomes (APO).

United States, Complications and side effects, Risk factors, Fetus, Fetal growth retardation, Pregnancy, Complications of, Pregnancy complications, Fetal diseases

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