Attachment and differentiation in vitro of trophoblast from normal and preeclamptic human placentas
Article Abstract:
Trophoblast cells from placentas from preeclamptic women may grow differently than trophoblast cells from placentas of healthy women. Trophoblast cells are fetal cells that invade the maternal tissue to form the placental connection between mother and child. Faulty placental growth is a predictor of preeclampsia. Researchers isolated and cultured trophoblast cells from placentas taken from five preeclamptic and five healthy women in a solution containing proteins found in maternal uterine tissues. Trophoblast coming from preeclamptic pregnancies showed diminished attachment and formation of networks compared with trophoblast from normal pregnancies.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Drug actions in preeclampsia: aspirin, but not magnesium chloride or dihydralazine, differentially inhibits cultured human trophoblast release of thromboxane and prostacyclin without affecting angiotensin II, endothelin-1, or leukotriene B4 secretion
Article Abstract:
Aspirin may be effective in treating pregnancies complicated by preeclampsia by inhibiting the production of some substances which influence the dilation and constriction of blood vessels. Preeclampsia is a serious complication of pregnancy involving hypertension and protein in the urine. Researchers obtained placental cells from preterm and term deliveries of both preeclamptic and normal pregnancies. When arachidonic acid was present, aspirin was effective in inhibiting placental cell production of prostanoids but not other substances which influence blood vessel tone in preeclamptic but not in normal placentas.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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Altered expression of gelatinase and surface-associated plasminogen activator activity by trophoblast cells isolated from placentas of preeclamptic patients
Article Abstract:
Altered activity of enzymes produced by placenta cells called trophoblasts may contribute to the development of preeclampsia. Enzyme analysis was done on trophoblast cells from normal deliveries and those with preeclampsia. In 60% of the placenta samples from patients with preeclampsia, an enzyme called gelatinase-B was present in a larger, inactivated form. This would result in a deficiency of the active form of the enzyme. Activity of the enzyme plasminogen activator was also lower in the placenta samples from the patients with preeclampsia.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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