Autogenic masculinization

Article Abstract:

Lichen sclerosus is a skin condition marked by itchy, white, flat pimples occurring on the external region of the vagina (vulva). Conventional treatment includes topical testosterone ointment applied to the infected area twice a day for six weeks or until the itching subsides. The dosage is then tapered during maintenance therapy. A 27-year-old woman with a history of lichen sclerosus came to an endocrine clinic for evaluation. She was a graduate student in biology and had access to testosterone. Since she had previously been treated with testosterone therapy, she prepared her own ointment, 7.5 milligrams applied seven to eight times a day for eight months. The patient had menstruated only twice since she stopped the medication and failed to menstruate again for one year. The patient complained of a painful enlarged clitoris and her voice had deepened. Excess hair, balding and weight changes were not reported. The patient was not sexually active. The patient was advised to stop applying the testosterone ointment and to use vitamin A treatments instead. The testosterone blood level dropped to normal two months later, at which time one normal menstrual period was reported. Although her voice remained deep one year later, normal menstrual cycling has resumed. This case study demonstrates how topical testosterone applications that are twice the recommended dosage can inhibit the production of estrogen, the female hormone essential for normal menstrual cycling. The loss of menstruation and deepened voice have not been previously reported after topical applications. (Consumer Summary produced by Reliance Medical Information, Inc.)

Drug therapy, Skin diseases, Testosterone, Vulvar diseases

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Obstetric management of 219 infants with hypoplastic left heart syndrome

Article Abstract:

Pregnancies affected by fetal hypoplastic left heart syndrome may proceed to at-term vaginal birth with routine obstetrical care. Researchers reviewed the prenatal care of 219 infants with the heart abnormality, usually treated surgically after birth. Seventy-four percent of infants were delivered vaginally and the remainder delivered by cesarean section. Ninety percent proceeded to the full term of pregnancy, and 63% were diagnosed with the defect after birth.

Care and treatment, Hypoplastic left heart syndrome

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The pharmacokinetics and efficacy of different estrogens are not equivalent

Article Abstract:

Estrogen replacement therapy may have different physiological effects depending on how it is administered. Both oral estrogen and estrogen patches increase bone density but only oral estrogen promotes healthy levels of cholesterol and lipids.

Physiological aspects, Transdermal medication, Transdermal drug delivery systems, Hormone therapy, Dosage and administration, Estrogen, Estrogens

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