BRCA1, BRCA2, and hereditary nonpolyposis colorectal cancer gene mutations in an unselected ovarian cancer population: relationship to family history and implications for genetic testing

Article Abstract:

A family history of cancer may not adequately detect people who might have a gene mutation predisposing them to cancer. Researchers tested 116 women with ovarian cancer for mutations in the BRCA1, BRCA2, hMSH1 and hMSH2 genes. The BRCA genes are linked to breast and ovarian cancer and the MSH genes are linked to colorectal cancer. Ten women had a BRCA1 mutation, one also had a BRCA2 mutation, and one each had one of the MSH mutations. Most had no serious family history of cancer and most of the 116 women who did tested negative for these mutations.

Testing, Cancer patients

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Field cancerization: why late "recurrent" ovarian cancer is not recurrent

Article Abstract:

Many cases of recurrent ovarian cancer may not be ovarian cancer at all but some other new tumor. Researchers used molecular techniques to analyze tissue samples from 13 ovarian cancer patients who developed recurrent cancer two to five years later. Samples from both tumors were analyzed. In 10 cases, the molecular characteristics of the recurrent tumor differed from those of the first tumor. This indicates that they were not recurrent ovarian cancer but a second tumor of a different organ, most likely the peritoneum.

Development and progression, Cancer, Cancer recurrence

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p53 mutations and microsatellite instability in ovarian cancer: yin and yang

Article Abstract:

Microsatellite instability is very common in ovarian cancer and can cause mutations in the p53 gene. Microsatellites are short repeated DNA sequences that occur throughout the chromosomes.

Research, Tumor suppressor genes

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