Development and characterization of an interleukin-2-transduced human ovarian carcinoma tumor vaccine not expressing major histocompatibility complex molecules
Article Abstract:
A cancer vaccine derived from interleukin-2 secretions from tumors may potentially be used to treat women with advanced ovarian cancer. Researchers genetically engineered a cancer vaccine by forcing a type of human ovarian cancer cell line to produce interleukin-2, an immune system chemical. The cells were injected into some laboratory mice, while others received injections of cells from a related cancer. Mice that received the cellular vaccine lived longer than mice that did not, and tumors disappeared in 25% of the vaccinated mice. The cells were eventually killed by high-dose radiation, but not by moderate doses. The vaccine may work by inducing the immune system to respond to the interleukin-2 tumor cells. Development of cancer vaccines derived from a patient's own cancer may have advantages over current vaccines.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Estrogen replacement in surgical stage I and II endometrial cancer survivors
Article Abstract:
Estrogen replacement therapy may not be contraindicated in women who have survived stage I or II endometrial cancer. The endometrium is the inner layer of the uterus. Researchers reviewed the outcomes of 123 women treated for stage I and II endometrial cancer, 62 of whom took estrogen replacement therapy after cancer treatment. Women who took estrogen had a similar death rate from recurrences of endometrial cancer (1.6%) as women who did not take estrogen. Estrogen therapy lowers the risk of cardiovascular disease and osteoporosis, both of which may outweigh the risk of cancer recurrence.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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