Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the I(kappa)B(alpha)/NF-(kappa)B pathway in limb girdle muscular dystrophy type 2A

Article Abstract:

Calpain 3 deficiency in limb girdle muscular dystrophy (LGMD) type 2A is associated with myonuclear apoptosis and profound perturbation of the I(kappa)B(alpha)/NF-(kappa)B pathway. Fluorescence microscopy has showed muscle biopsies of LGMD2A patients present apoptotic features associated with subsarcolemmal localization of NF-(kappa)B and selective nuclear accumulation of I(kappa)B(alpha).

United Kingdom, France, Spain, Scotland, Lebanon, Physiological aspects, Cellular signal transduction, Cytochemistry, Muscular dystrophy, Calpain

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Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy

Article Abstract:

Research presented concerns the role of tumor necrosis factor in hepatitis infection and liver failure. Research suggests that a matrix metalloproeinase (MMP) inhibitor called batimastat (BB-94) prevents necrosis and apoptosis of liver cells and may be of therapeutic use in treating cancer.

Japan, Belgium, Statistical Data Included, Models, Hepatitis, Viral, Viral hepatitis, Liver failure, Tumor necrosis factor, Leukocytes, White blood cells

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Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase

Article Abstract:

Entrapping the oncoprotein BCR-ABL in a nucleus can be a therapy for selectively killing chronic myelogenous leukemia cells. Inhibiting the BCR-ABL tyrosine kinase can stimulate it to enter the nucleus, where its nuclear export can be blocked by combining STI571 with leptomycin B.

Italy, Protein tyrosine kinase, Protein-tyrosine kinase, Chronic myeloid leukemia

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