Cartilage markers in synovial fluid in symptomatic knee osteoarthritis
Article Abstract:
Cartilage oligomeric matrix protein (COMP) and aggrecan levels may be valuable in detecting and monitoring early and ongoing osteoarthritis disease. COMP and aggrecan are two markers of cartilage turnover in joint fluid. COMP and aggrecan levels were measured in knee joint fluid samples from 45 patients with documented grade I osteoarthritis, 45 matched patients with long-term knee pain but undocumented osteoarthritis, and eight healthy volunteers (control group). Patients with osteoarthritis had the highest aggrecan to COMP ratios followed by those with long-term knee pain and the control group.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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Cartilage macromolecules in knee joint synovial fluid: markers of the disease course in patients with acute oligoarthritis
Article Abstract:
Concentration of cartilage macromolecules in the synovial fluid of arthritic joints may predict the prognosis for patients with sudden onset of joint inflammation. Researchers measured the concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) in 25 patients with knee arthritis. Aggrecan concentrations and aggrecan/COMP concentration ratios were lower in patients who later developed chronic disease than in those in whom arthritis was transient. Elevated aggrecan in joint fluid may indicate ongoing cartilage repair that prevents progressive disease.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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Radiographic osteoarthritis of the knee classified by the Ahlback and Kellgren & Lawrence systems for the tibiofemoral joint in people aged 35-54 years with chronic knee pain
Article Abstract:
Two scoring systems for evaluating patients with long-term knee pain appear to provide similar results. Two hundred four people aged 35 to 54 years with long-term knee pain were identified through a mailed questionnaire and examined by x-ray using two grading systems: Ahlback and Kellgren & Lawrence. Of this population, 1.5% were identified as having a lower grade knee osteoarthritis and 0.9% as having more advanced disease as determined by the Kellgren-Lawrence system. The Ahlback system identified 1.1% of the population with similar disease.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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