Cervical fetal fibronectin correlates to prostaglandin E2-induced cervical ripening and can be identified in cervical tissue

Article Abstract:

Cervical ripening in pregnancies at term may be associated with the local action of prostaglandin E2 and its effect on fetal fibronectin levels in the uterine cervix. Researchers evaluated the effect of prostaglandin E2 gel on the cervices of 28 women with at-term pregnancies and low cervical scores. Cervical fetal fibronectin levels were low in all women tested. A tenfold increase in fetal fibronectin was detected in women in whom prostaglandin gel induced cervical ripening. The amniotic membranes secrete prostaglandin E2, which may be important to cervical ripening at the end of pregnancy.

Cervix uteri, Fibronectins, Incompetent cervix, Synthetic prostaglandins E

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Matrix metalloproteinases and their inhibitors in the cervical mucus plug at term of pregnancy

Article Abstract:

The presence of matrix metalloproteinases (MMPS) and their inhibitors in the cervical mucus plug obtained during active labor at term are evaluated. Results reveal that proteolytic or proteolytic effects of MMP and tissue inhibitor of matrix metalloproteinase could play a part in the function of cervical mucus plug of pregnancy.

United States, Science & research, Complications and side effects, Pregnancy, Complications of, Pregnancy complications, Cervix mucus, Matrix metalloproteinase inhibitors

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Proteoglycans and hyaluronan in human fetal membranes

Article Abstract:

Changes in the amount of proteoglycans, collagen, and hyaluronan probably occur as fetal membranes grow and mature during the last few weeks of pregnancy. Research on the strength of fetal membranes is important to shed light on the cause of premature rupture of the membranes.

Fetal membranes, Premature rupture of membranes, Premature rupture of the membrane

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