Changing funding patterns in tuberculosis

Article Abstract:

The changing funding patterns found in the tuberculosis (TB) research and development (R&D) since 1981 are discussed. The proper choice of funding strategies promoting the combination of different expertise of academic institutions, clinics and industry are very important. Hence new products should be developed for replacing current and insufficient diagnostic, treatment and prevention measures developed in the middle of the twentieth century.

Product development, Financial management, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Drugs, Tuberculostatic Preparations, Biotechnology industry, Biotechnology industries, Finance, Prevention, Tuberculosis, Antitubercular agents, Company financing

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Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis

Article Abstract:

Mycobacterium tuberculosis phagosomes are secluded from the cytosolic major histocompatibility complex I (MHC-I) processing pathway and that mycobacteria- infected cells lose their antigen-presenting capacity. Mycobacteria induce apoptosis in macrophages, causing the release of apoptotic vesicles that carry mycobacterial antigens to uninfected antigen-presenting cells.

Mycobacteria, Antigen presenting cells, Mycobacterium, Apoptosis

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Cholesterol glucosylation promotes immune evasion by Helicobacter pylori

Article Abstract:

Studies have identified the gene hp0421 as encoding the enzyme cholesterol-alpha-glucosyltransferase responsible for cholesterol glucosylation. A mechanism regulating the host-pathogen interaction whereby glucosylation of a lipid tips the scales towards immune evasion or response is proposed.

Health aspects, Genetic aspects, Protein folding, Helicobacter pylori, Immunogenetics

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