Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect
Article Abstract:
Persons deficient for protein S due to a genetic mutation appear to be at greater risk for developing deep venous blood clots. Protein S helps regulate the anticoagulation process. Deep venous blood clot risk was analyzed in 122 members of a family that had 44 individuals with the protein S defect. Those carrying the mutation were 11.5 times more likely to develop a deep venous blood clot compared to those not carrying the mutation, even after controlling for weight and smoking history. Protein S blood levels were a distinguishing factor between those with the defect and those without the defect.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1998
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The frequency of genes for hemochromatosis in patients attending a health appraisal clinic
Article Abstract:
Measuring blood levels of iron may not detect all people who have a gene mutation predisposing them to hemochromatosis. Hemochromatosis is a genetic diseased that causes iron deposits in various organs. In a study of 10,198 people, most of those with the gene mutation would have been missed by the usual blood tests.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 2000
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Mutations of the angiotensinogen gene and the risk for heart disease and stroke
Article Abstract:
The M235T and the T174M mutations in the gene for angiotensinogen do not appear to increase the risk of heart disease or stroke, either alone or together. Angiotensinogen is a protein in the body that can affect blood pressure.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 2001
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