Haemophilus parainfluenzae causing sexually transmitted urethritis: report of a case and evidence for a beta-lactamase plasmid mobilizable to Escherichia coli by an Inc-W plasmid

Article Abstract:

Haemophilus parainfluenzae (H. parainfluenzae) is an organism that can cause sexually transmitted urethritis (inflammation of the urethra). Certain members of this group of bacteria are resistant to penicillin because they produce an enzyme called beta-lactamase, which destroys the drug. This is a consequence of the action of a beta-lactamase plasmid (a small genetic element located in the bacterium). The case report is presented of a 32-year-old man who had developed a urethritis following sexual intercourse with women in Algeria while on a work assignment. Penicillin had not been successful against his condition. An account is presented of the attempts to determine which organism caused the patient's urethritis. It was discovered to be a beta-lactamase-producing H. parainfluenzae. Plasmid analysis was carried out on the isolate, yielding a finding of a small plasmid that could be mobilized to (moved to) Escherichia coli. The plasmid also showed beta-lactamase activity in this organism. The possible evolutionary routes taken by this and related plasmids as they move between microorganisms are discussed. It is possible that H. parainfluenzae is a source for such plasmids, which then move to other bacteria, spreading antibiotic resistance. (Consumer Summary produced by Reliance Medical Information, Inc.)

Sexually transmitted diseases, Research, Case studies, Diagnosis, Causes of, Disease transmission, Hemophilus infections, Beta lactamases, Urethritis, Nongonococcal, Nongonococcal urethritis

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Comparative in vitro susceptibility of a tetracycline-resistant chlamydia trachomatis strain isolated in Toulouse (France)

Article Abstract:

A strain of Chlamydia trachomatis that is resistant to tetracycline is reported. It was isolated from a French woman who was treated for chlamydia with tetracycline, the usual treatment, and claimed to be compliant with the treatment. Laboratory research revealed that the organism was resistant to tetracycline but susceptible to azithromycin, erythromycin, ofloxacin, and pristinamycin. Thirty-four other chlamydia isolates found in Toulouse patients were susceptible to all that antibiotics.

Health aspects, France, Drug resistance in microorganisms, Microbial drug resistance, Chlamydia trachomatis, Tetracycline, Tetracyclines

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