Combination of laser-therapy with 0.5 Idoxuridine cream in the treatment of therapy-resistant genital warts in male patients: an open study

Article Abstract:

The response of genital warts to various available treatments is generally inconsistent. In some patients, spontaneous regression occurs. Others respond to conventional therapies, including painting with podophyllin, cryosurgery, and laser therapy. However, other patients have genital warts that are resistant to treatment. The use of 0.25 percent idoxuridine (5-iodo-2-deoxuridine) has demonstrated efficacy in treating vulvar warts of short duration; treatment of penile warts of short duration was better accomplished using a 0.5 percent idoxuridine preparation. The current study assesses the effect of using a 0.5 percent idoxuridine cream immediately after laser therapy as a treatment for long duration, resistant penile warts. Forty heterosexual males who had penile lesions for an average of 12.9 months were included in the study. Many of their female partners also had genital warts. All had received podophyllin therapy repeatedly. Twenty-six were treated previously with lasers and experienced remissions, the longest lasting six weeks. After lesion verification, each was painted with 10 percent acetic acid and treated with carbon dioxide laser equipment. Immediately after laser exposure, 0.5 percent idoxuridine was applied to the treated sites and then twice daily for 14 days. Follow-up examinations were conducted up to 12 weeks, and those who did not respond were retreated. Thirty-two patients had no evidence of lesions after the initial treatment. The reminder had a lesser response or no response. After three months, 85 percent of all patients were considered to be completely healed. To further validate this procedure, it would be appropriate to conduct placebo controlled studies with a longer post-treatment follow-up period and a larger study group. (Consumer Summary produced by Reliance Medical Information, Inc.)

Surgery, Idoxuridine

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A comparative study of topical analgesia with a Lidocaine/ Prilocaine Cream (EMLA) and infiltration anesthesia for laser surgery of genital warts in men

Article Abstract:

Local anesthetics are used to relieve pain during minor surgical procedures. Injectable lidocaine is frequently used, but the injection is often accompanied by significant discomfort and pain. A mixture of the anesthetics lidocaine and prilocaine (EMLA), when applied locally, penetrates the skin and mucosa and is effective in blocking pain. One hundred male patients with genital warts were randomly split into two groups. Local anesthesia was applied by either injection or topical application (EMLA), and the pain the patient experienced during the laser treatment was measured; pain as a result of the laser therapy was also measured. Infiltration anesthesia provided slightly better local anesthesia than did the cream. However, the combined pain experienced by the patient was less in the EMLA group than in the injected anesthesia group. These results suggest that the use of EMLA prior to surgical intervention should be the anesthetic of choice in laser surgery for genital warts. (Consumer Summary produced by Reliance Medical Information, Inc.)

Methods, Usage, Analgesics, Local anesthesia, Lidocaine, Prilocaine hydrochloride

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History of genital warts in 10,838 women 20 to 29 years of age from the general population: risk factors and association with Papanicolaou smear history

Article Abstract:

Women who have had genital warts (GW) caused by the human papillomavirus (HPV) could be at higher risk for cervical cancer than the general population. Of 10,838 women interviewed, 17% reported ever having GW. Increase in the lifetime number of sexual partners was associated with an increase of GW. The pattern of risk factors associated with GW is in accord with those for cervical cancer. The type of HPV that causes GW probably does not cause cervical cancer, but may serve as a marker for those types that are known to be associated with the condition.

Risk factors, Cervix dysplasia

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