Combination treatment with zidovudine, didanosine, and nevirapine in infants with human immunodeficiency virus type 1 infection

Article Abstract:

Infants who are infected with HIV at birth should begin treatment with AIDS drugs within the first few months of birth. Researchers tested the combination therapy of zidovudine, didanosine and nevirapine in eight infants who had been infected at birth. Six infants began treatment before their fifth month. Analysis of blood samples revealed that the treatment substantially reduced levels of the virus as measured by viral RNA. In seven infants, the reduction was greater than 95%. Viral RNA levels began to rise again in five infants, who were shown to have viral strains resistant to the drugs.

Evaluation, Drug therapy, Zidovudine, Didanosine

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A trial of three antiretroviral regimens in HIV-1-infected children

Article Abstract:

The safety, tolerability, and the activity of three regimens of antiretroviral therapy in HIV-1-infected children, phase 1-2 trial are evaluated. The results indicate that the children who received stavudine, lamivudine, nevirapine and nelfinavir had plasma HIV-1 RNA levels of less than 400 copies per milliliter as compared to those who received reverse-transcriptase inhibitors alone.

United States, Science & research, Children, Health aspects, Care and treatment, Research, HIV infection, HIV infections, Antiviral agents, Antiretroviral agents

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The changing face of pediatric HIV-1 infection

Article Abstract:

The use of combinations of AIDS drugs that include a protease inhibitor have dramatically reduced mortality rates among HIV-infected children and teenagers. However, most new HIV infections in children occur in developing countries that cannot afford most AIDS drugs.

Editorial, Patient outcomes, Mortality

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