Consensus statement
Article Abstract:
Future research on the human immunodeficiency virus (HIV) should address the associations between virus production, indicators of disease progression, and potential drug treatments. A broad-based group of researchers, drug company representatives, government officials, and members of the community summarized goals and guidelines for future research projects on HIV and itemized current strategies for assessing disease progression. Proposed studies should assess the usefulness of various indicators of HIV disease progression, particularly HIV RNA. Other studies should further test the relationship between the changes in virus type, disease progression, and response to drug treatment. Researchers should consider standardizing testing procedures and data reporting in order to allow for better study comparisons and pooling of data. The storage of study samples would be helpful for future comparison. Currently used indicators for disease progression include measures of CD4 count and percentage, beta-2 microglobulin, delayed type hypersensitivity, HIV RNA and DNA, and p24.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Effect of antibody to HIV-1 Tat protein on viral replication in vitro and progression of HIV-1 disease in vivo
Article Abstract:
Antibodies to the HIV Tat protein may delay the progression of HIV infection. The Tat protein is involved in regulating gene transcription in the virus. Researchers took blood samples from three healthy volunteers and infected blood cells with HIV in the presence and absence of a monoclonal antibody against the Tat protein. The Tat antibody significantly reduced viral replication as measured by levels of p24 antigen. Blood samples taken from 10 HIV-infected hemophiliacs over a period of 7 to 9 years were tested for naturally-produced Tat antibodies and viral p24 antigen. In the beginning of the infection, Tat antibody levels were high and p24 antigen levels were low. As the infection progressed, Tat antibody levels dropped and p24 antigen levels increased. One patient whose disease did not progress rapidly had high Tat antibody levels throughout the study.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Dynamics of cell-free viral burden in HIV-1-infected patients
Article Abstract:
Discrepancies between studies that have measured cell-free blood viral levels may reflect the fact that blood samples were analyzed at different times. Researchers measured blood viral RNA during several different time periods in 17 HIV-infected people whose disease had progressed rapidly and 20 whose disease had progressed slowly. In over half of the rapid progressors, blood viral RNA increased rapidly but their disease was not clinically more severe than the rapid progressors whose viral levels did not increase.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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