Cross-presentation of caspase-cleaved apoptic self antigens in HIV infection
Article Abstract:
The self-reactive effector [CD8.sup.+] T has contributed to the systemic immune activation during chronic HIV infection. The caspase-dependent cleavage of protein associated with apoptic cells have played a major role in the induction of self-reactive [CD*.sup.+] T cells responses, as the caspase-cleaved fragments are targeted to the processing machinery and are cross-presented by dendritic cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Building the bionic T cell
Article Abstract:
Tumor immunologists have described a new strategy that has produced striking antitumor effects in mouse models by using T cells. Results highlight that the increase in costimulation can boost tumor immunotherapy providing new strategies to accomplish this boost in of adoptive T cell therapy.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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