Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity
Article Abstract:
Dendritic cells (DCs) loaded with heart-specific self peptide induce CD4(super +1) T-cell-mediated myocarditis in nontransgenic mice. In vivo experimental evidence is provided to support that the combined action of innate and adaptive immunity on dilated cardiomyopathy (DCs) triggers autoimmune heart disease, relapses and cardiomyopathy.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomypathy
Article Abstract:
Iron-overload cardiomypathy is considered to be the most significant factor in patient survival. Results indicate that cardiac LVDCCs are important transporters of iron into cardiomyocytes under iron-overload conditions and are representing a new therapeutic target to reduce the cardiovascular burden from iron overload.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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The tyrosine kinase p56(super lck) is essential in coxsackievirus B3-mediated heart disease
Article Abstract:
The sarcoma family kinase p56(super lck) is involved in the replication of coxsackievirus B3. Mice who lacked the gene for this enzyme were completely protected from coxsckievirus B3-induced heart disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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