Detection of Chlamydia trachomatis in semen by the polymerase chain reaction in male members of infertile couples

Article Abstract:

Polymerase chain reaction (PCR) may be more effective than a deoxyribonucleic acid (DNA) probe for detecting Chlamydia trachomatis (C. trachomatis) in the semen of male members of infertile couples. An immune response to a subclinical C. trachomatis infection may be the underlying cause of infertility in some of these couples. PCR was used to test for C. trachomatis in semen samples from the male members of 28 infertile couples who had negative DNA probe results for a C. trachomatis infection. Thirty-nine percent of the semen samples were positive for C. trachomatis using PCR. Among the 11 men with positive PCR results, 46% had immunoglobulin G (IgG) or immunoglobulin A (IgA) antibodies against their own sperm. Forty-six percent of these men's wives had IgG or IgA antibodies against their husband's sperm, and 55% had immunoglobulin M antibodies against C. trachomatis.

Analysis, Semen, Infertility, Male, Male infertility

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Detection of Chlamydia trachomatis by the polymerase chain reaction in the cervices of women with acute salpingitis

Article Abstract:

The polymerase chain reaction (PCR) may be more effective than other methods for diagnosing Chlamydia infection in women with salpingitis. Salpingitis is inflammation of the fallopian tubes. Among 35 women from whom a sample of cervical tissue was tested for Chlamydia trachomatis using PCR, 15 had salpingitis and 20 did not (control group). Sixty percent of the women with salpingitis were positive for Chlamydia trachomatis using PCR, compared with 20% of the women in the control group. Only two women from each group had a positive cervical tissue culture for Chlamydia trachomatis. Women with salpingitis or cervicitis (inflammation of the cervix) are often difficult to diagnose because no cause of infection can be found. Levels of Chlamydia trachomatis in the cervix may sometimes be too low to culture in the laboratory.

Salpingitis

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