Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction
Article Abstract:
The percentage of peripheral-blood mononuclear cells (PBMC) infected with HIV type 1 (HIV-1) in HIV-positive individuals may be 10 times higher than previously believed. PBMC are a type of white blood cell (WBC). The percentage of PBMC infected with HIV-1 provirus, a form of HIV-1 virus, was analyzed in patients with different stages of HIV-1 infection. Among 56 patients infected with HIV-1, the percentage of PBMC infected with HIV-1 varied from 0.1 to 13.5%. The average percentage of PBMC infected with HIV-1 was 6.6% in 13 patients with persistent swelling of the lymph nodes, 4.6% in 19 patients with AIDS but only 1.6% in five patients with Kaposi's sarcoma. In HIV-1 positive patients without any symptoms, the average percentage of PBMC infected with HIV-1 was 0.9%. None of the PBMC from 11 HIV-1 negative individuals were infected with HIV-1. There may be an association between the percentage of WBCs infected with HIV-1 and the severity of illness in HIV-positive individuals.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1992
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Residual HIV-1 disease in the era of highly active antiretroviral therapy
Article Abstract:
Two 1999 reports illustrate that HIV may continue to persist in the human body despite treatment with highly active antiretroviral therapy. This combination therapy usually includes a protease inhibitor that suppressed viral levels to undetectable levels. Both reports followed up HIV patients on combination therapy whose blood viral levels were undetectable and found that the virus was still present in some immune cells. It is possible that new drug treatments will be needed to eradicate the virus that is hiding out in cells once antiretroviral therapy suppresses it in the blood.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
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HIV and GB virus C: can two viruses be better than one?
Article Abstract:
The GB virus C commonly coinfects patients with Human Immunodeficiency Virus (HIV). A number of studies have demonstrated a surprising survival benefit among patients who are coinfected with the two viruses, as compared to those who are infected with HIV only.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
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