Disposition of maternal ketoconazole in breast milk
Article Abstract:
Infants exposed to the drug ketoconazole through breast milk may receive very small amounts of the drug without harm. A breastfeeding mother was prescribed ketoconazole treatment for a fungal infection. Halfway through the 10-day treatment, she asked doctors for information about the potential effects of ketoconazole on her baby through breast milk. She had not observed any changes in the baby, and had not experienced any side effects herself. She completed the treatment, and provided doctors with samples of her milk for analysis. A laboratory performed the analysis, and developed a formula for figuring how much ketoconazole was in the breast milk at any given time. The highest level of ketoconazole in the milk was found 3.25 hours after a dose was taken, and even this amount was small.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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The safety of omeprazole during pregnancy: a multicenter prospective controlled study
Article Abstract:
The drug omeprazole appears to be safe when used during pregnancy. This anti-ulcer drug is also used to treat heartburn, which affects many pregnant women. Researchers compared the rate of birth defects in infants of 113 women who took omeprazole during pregnancy with the rate in pregnant women who took other drugs, including anti-histamines. The rate of birth defects was similar in both groups. Birth weights, gestational age at delivery and the number of premature births were also similar.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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Pregnancy outcome after in utero exposure to itraconazole: a prospective cohort study
Article Abstract:
The antifungal drug itraconazole (Sporanox) appears to be safe when taken during pregnancy, according to a study of 229 women. However, the rate of miscarriage was slightly higher compared to a group of women who did not take the drug, and birth weight was lower.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2000
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