Human skin Langerhans cells are targets of dengue virus infection

Article Abstract:

Research presented concerns the development and progression of dengue virus infections introduced into human skin via mosquitoes. This study suggests the dengue virus targets Langerhans cells, a type of dendritic cell.

United States, Statistical Data Included, Infection, Skin, Antigen presenting cells, Dengue viruses, Dengue virus, Immunohistochemistry

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Broad HIV-1 neutralization mediated by CD4-binding site antibodies

Article Abstract:

Antibody adsorption and elution from gp120 variants are used for mapping the neutralizing specificities of the two most broadly reactive sera to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are obtained in some HIV-1-infected individuals and improved vaccine immunogens can be derived.

Science & research, CD4 lymphocytes, Immunogenetics

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Drug Resistance Patterns, Genetic Subtypes, Clinical Features, and Risk Factors in Military Personnel with HIV-1 Seroconversion

Article Abstract:

Because regular testing of military personnel for HIV infection allows early diagnosis, there can be insights into the epidemiology of transmission. A total of 95 HIV positive patients answered questionnaires on CD4 cell counts, HIV-1 RNA levels, and nucleic acid sequences for drug-resistant mutations and HIV-1 genetic subtype. The percentage of HIV-1 non-subtype B infection and antiretroviral drug--resistant mutations was relatively high with seven subtype E infections. Of 31 patients who had never had antiretroviral drug therapy, 26% were already somewhat drug resistant, with mutations in the reverse transcriptase or protease gene associated with drug resistance.

Health aspects, Statistics, HIV infection, HIV infections, Drug resistance in microorganisms, Microbial drug resistance, Military personnel

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