Drug interactions and protease inhibitor therapy in the treatment of HIV/AIDS

Article Abstract:

Protease inhibitor therapy has become very important in treatment of HIV/AIDS. Protease inhibitors undergo significant oxidative liver metabolism involving the Cytochrome P-450 (CYP450) enzyme system. They are therefore substrates, inhibitors and/or inducers of CYP450. When protease inhibitors are used with certain other drugs that are CYP450-dependent, they may change pharmacokinetics and cause changes in bioavailability. That can lead to changed clinical effect, drug interaction. The most interactive of the 4 licensed protease inhibitors is ritonavir, the least interactive saquinavir.

Analysis, Drug interactions

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Protease inhibitors

Article Abstract:

A category of drugs that interfere with the HIV life cycle called protease inhibitors may prove to have a significant impact on controlling this infection. These drugs include ritonavir, saquinavir, and indinavir. They appear to be most effective when taken in combination with other retroviral therapies. They may, however, be ineffective or harmful if taken with certain other drugs or not taken as directed. Monthly combination therapy may cost between $800 and $900.

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News from the 5th Conference on Retroviruses and Opportunistic Infections

Article Abstract:

Highly active antiretroviral therapy (HAART) has changed some aspects of HIV infection for the better. Notable changes include fewer opportunistic infections, lower mortality rates, and altered costs of medical care. For example, hospitalization costs decreased while medication costs soared. HAART may build up the overall immune strength of patients.

Care and treatment, Antiviral agents, Opportunistic infections

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