Effect of osteoprotegerin and osteoprotegerin ligand on osteoclast formation by arthroplasty membrane derived macrophages

Article Abstract:

Osteoprotegerin ligand causes macrophages to differentiate into bone-absorbing cells. This could explain why many artificial joints fail. Metallic wear might attract macrophages, which would then become bone-absorbing cells.

Research, Macrophages

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Arthroplasty implant biomaterial particle associated macrophages differentiate into lacunar bone resorbing cells

Article Abstract:

The body's reaction to the shedding of tiny particles of artificial joint material appears to play an important role in joint loosening for noninfectious reasons. To simulate the possible effects of natural wear, tiny particles of the materials commonly used in artificial joints were injected under the skins of mice. Scavenging white blood cells were isolated from the resultant inflammatory reaction and cultured on bone slices. Microscopic examination revealed strong bone-dissolving activity by those cells. Plastics and titanium elicited a stronger response than chromium-cobalt, although this may not reflect the real life situation.

Complications and side effects, Artificial joints, Joint prostheses, Arthroplasty

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Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis

Article Abstract:

Immature cells called mononuclear phagocytes that digest waste may develop into cells that absorb and remove bone called osteoclasts under the right conditions. This process may help explain the destructive bone cycle seen in patients with rheumatoid arthritis. Mononuclear phagocytes from joint tissue and blood samples of patients with rheumatoid arthritis were mixed with osteoblast cells, macrophage stimulating factor, and vitamin D3. Tests indicated that the phagocytes developed into osteoblasts. Additional tests were performed on phagocytes not exposed to osteoblasts as controls.

Causes of, Monocytes

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