Effects of hydrogen peroxide on the metabolism of human rheumatoid and osteoarthritic synovial fibroblasts in vitro

Article Abstract:

Inflammatory diseases of the joints, such as rheumatoid arthritis, are accompanied by the migration of white blood cells (polymorphonuclear leukocytes) and immune system cells (macrophages) into the joint tissue. Once inside the joint, these cells make and release oxygen radicals (a highly reactive molecule of oxygen with an extra electron) and hydrogen peroxide. These substances can cause further damage and destruction of the joint tissue. There are several different ways in which these substances can damage tissue and it has been suggested that they may prevent joint cells from making specific proteins that are required for maintaining normal joint structure. To determine how hydrogen peroxide causes damage to joint tissue, samples of joint tissue were taken from patients with rheumatoid arthritis and osteoarthritis (a degenerative form of arthritis characterized by loss of cartilage). The tissue samples were grown in culture with and without hydrogen peroxide. In both types of tissue samples treatment with hydrogen peroxide inhibited the synthesis of DNA (the genetic material required for normal cell growth and replication) and the synthesis of hyaluronic acid, which is required for maintaining normal joint structure. The inhibitory effects of hydrogen peroxide on these cell functions were related to the dose used and increased as the dose of hydrogen peroxide was increased. These findings indicate that hydrogen peroxide interferes with the production of substances required for normal joint cell function. (Consumer Summary produced by Reliance Medical Information, Inc.)

Research, Joints, Joints (Anatomy), Body fluids

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Analysis of T cell subsets present in the peripheral blood and synovial fluid of reactive arthritis patients

Article Abstract:

Synovial fluid from the joints of patients with reactive arthritis appears to contain more activated T-type white blood cells than are found in blood samples. Reactive arthritis can develop after bacterial infection. Researchers compared synovial fluid and blood samples from 14 patients with reactive arthritis, and found a higher percentage of specific types of T cells in the fluid samples, compared to blood samples. CD4+ and CD8+ T cells showed evidence of recent activation. These cells may be involved in the development or progression of joint inflammation.

T cells, Infectious arthritis

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Value of synovial fluid interleukin-1beta determination in predicting the outcome of psoriatic monoarthritis

Article Abstract:

High levels of interleukin-1beta (IL-1beta) in joint fluid may predict progression of psoriatic arthritis in a single joint to arthritis in multiple joints. Researchers measured various factors indicative of inflammation in joint fluid samples from the knees of 18 patients with psoriatic monoarthritis of less than six months duration. Patients with high levels of IL-1beta were more likely to develop polyarthritis within three years. In addition, the number of affected joints rose with an increase IL-1beta concentrations.

Prognosis, Interleukin-1, Psoriatic arthritis

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