Elevated serum lipids in hypogonadal men with and without hyperprolactinemia
Article Abstract:
The risk for developing hyperlipidemia, which is increased levels of blood lipids such as cholesterol, was assessed in men with hypogonadism, the impaired secretion of the testicles. The study included: 18 men with both a deficiency of the male hormone testosterone and a prolactin-secreting tumor of the pituitary; 15 men with hypogonadism resulting from an underlying disorder but with normal prolactin levels; and 33 normal subjects. Prolactin, a hormone produced by the pituitary, is involved in breast development, milk formation during pregnancy, and metabolic effects similar to those of growth hormone. Hyperprolactinemia, or increased levels of prolactin in the blood, may lead to amenorrhea or absence of menstruation in women and decreased sexual potency in men. Hypogonadal men with normal or high prolactin levels had increased levels of cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides as compared with normal subjects. The high-density lipoprotein levels did not differ among the three groups of men. The results show that hypogonadism with and without hyperprolactinemia may be associated with elevated levels of cholesterol, LDL cholesterol, and triglycerides, suggesting that lipid levels should be monitored in hypogonadal men. The individual's blood lipid levels may influence the decision to treat the testosterone deficiency associated with hypogonadism. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1989
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Long-Term Mortality after Transsphenoidal Surgery for Cushing Disease
Article Abstract:
People with Cushing's disease who have their pituitary tumor removed appear to have an excellent prognosis. Cushing's disease is caused by excessive levels of a pituitary hormone called ACTH. This is often caused by a pituitary tumor. Researchers analyzed mortality rates among 161 people who had pituitary surgery to treat Cushing's disease. Ninety percent were cured and five- and ten-year survival rates were 99% and 93%, respectively.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1999
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The Effect of Thyroid Hormone on Skeletal Integrity
Article Abstract:
Excess thyroid hormones may have a damaging effect on bones. A review of the medical literature reveals that excess thyroid hormone due to hyperthyroidism or from treatment to suppress thyroid-stimulating hormone (TSH) has a particularly damaging effect on cortical bone, such as the bone in the hip and forearm. Women who receive thyroid hormone replacement therapy should have regular bone exams using densitometry.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1999
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