Limitin: an interferon-like cytokine that preferentially influences B-lymphocyte precursors
Article Abstract:
Research is presented on an inferon-like cytokine called limitin and its ability to either arrest the growth of or kill lympho-hematopoietic cells. Issues discussed include limitin's inhibition of B lymphopoiesis, despite its inability to influence either myelopoiesis or erythropoiesis; and limitin's use of interferon receptors, which may indicate a previously unknown interferon prototype.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer
Article Abstract:
Regulation of small 21-23-nucleotide non-coding ribonucleic acids, (miRNA), which de-targets rather than targets gene expression and functions at the post-transcriptional level, might provide a unique means for overcoming the limitations of gene delivery systems. A study demonstrates that, by preventing transgene expression in hematopoietic lineages while permitting high levels of expression in nonhematopoietic cells, miRNA regulation could enable stable gene transfer in the absence of an immune response.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Blasting away leukemia
Article Abstract:
CD44, a widely distributed glycoprotein, has been found to deliver a differentiation signal to leukemic blast cells that can perhaps be exploited for new therapies for acute myeloid leukemia. CD44-specific antibodies have been used successfully in experimental animals in spite of potential complications.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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