Endometrial morphology in asymptomatic postmenopausal women

Article Abstract:

The incidence of cancer of the endometrium, the inner lining of the uterus, is 0.72 per 1,000 women. Biopsy, or tissue sampling, of the endometrium has been shown to be specific and sensitive in detecting endometrial cancer in patients with symptoms of the disease. However, the benefits of general screening for endometrial cancer have not been demonstrated, especially for women who have stopped menstruating and are without symptoms. One study indicated that screening detected endometrial cancer in only 50 percent of women with a high risk of developing the disease. However, in another study of 2,586 postmenopausal women without symptoms, the incidence of endometrial cancer was estimated at 6.96 per 1,000 women, leading to a recommendation of screening by biopsy for all women over 45 years of age. There is limited information about the microscopic features of endometrial tissue of women without symptoms of endometrial cancer who are near or past menopause. Endometrial biopsy specimens were obtained from 801 postmenopausal women before they received hormone replacement therapy. Endometrial cancer was detected in one patient. Atypia, or unusual tissue features, was found in four women. Atrophy, or tissue wasting, was diagnosed in 373 patients. Proliferation, or rapid cell reproduction, was detected in 133 women. Fifty-four women had secretory endometrial tissue, and 41 had hyperplasia, or overgrowth of normal tissue. The amount of tissue was not sufficient for diagnosis in 195 cases. These findings indicate that endometrial biopsy screening of all postmenopausal women does not detect enough cases of cancer to justify the effort. (Consumer Summary produced by Reliance Medical Information, Inc.)

Evaluation, Testing, Medical screening, Health screening, Endometrial cancer, Endometrium, Endometrial biopsy

---

Is bleeding a predictor of endometrial hyperplasia in postmenopausal women receiving hormone replacement therapy?

Article Abstract:

Prolonged bleeding in women receiving only conjugated estrogens for hormone replacement therapy may indicate a risk of endometrial hyperplasia. Endometrial hyperplasia is abnormal cell growth in the lining of the uterus. Of 62 cases of endometrial hyperplasia diagnosed in women receiving either unopposed estrogen or estrogen combined with progestin, 57 received estrogen alone, accounting for 92% of all cases. Many of the 57 women with hyperplasia from the estrogen-only group had more bleeding days than the rest of the 283 women in the group not diagnosed with endometrial hyerplasia.

Diagnosis, Causes of, Hormone therapy, Uterine bleeding, Uterine hemorrhage, Endometrial hyperplasia

---

Reduced thermoregulatory null zone in postmenopausal women with hot flashes

Article Abstract:

Postmenopausal women who have hot flashes appear to have a smaller interval between the threshold for sweating and the threshold for shivering. Therefore, a small rise in body temperature can trigger a hot flash in these women, but not in women with a normal interval between these two thresholds.

Statistical Data Included, Body temperature, Body temperature regulation

Similar abstracts:

• Abstracts: The role of vaginal scan in measurement of endometrial thickness in postmenopausal women. Changes in circulating alphafetoprotein following administration of mifepristone in first trimester pregnancy
• Abstracts: A pilot trial of chemohormonal therapy for metastatic prostate carcinoma. Small testicles with impaired production of sperm in adult male survivors of childhood malignancies
• Abstracts: Comparison of continuous versus sequential estrogen and progestin therapy in postmenopausal women. Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist plus medroxyprogesterone acetate
• Abstracts: Enterococcal meningitis in an HIV positive haemophilic patient. Assessment of fetal-maternal haemorrhage in mothers with hereditary persistence of fetal haemoglobin
• Abstracts: Dental amalgam: designs for research in human populations. A proud achievement for American dentistry. Factors contributing to mercury exposure in dentists

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.