Eradication of Helicobacter pylori infection in primary low-grade gastric lymphoma of mucosa-associated lymphoid tissue
Article Abstract:
Eliminating Helicobacter (H.) pylori infection may improve or cure gastric lymphoma of mucosa-associated lymphoid tissue (MALT). Twenty-six patients diagnosed with low-grade gastric MALT lymphoma and H. pylori infection began treatment with antibiotics and bismuth. H. pylori was eradicated in 25 of the patients. The patients were re-evaluated by endoscopic biopsy within six months of treatment and every three to six months thereafter. The lymphoma regressed in 15 patients, including one patient who had relapsed after chemotherapy. Five patients were completely cured and 10 continued to have mild cellular abnormality but no lymphoma. This and other data suggest a connection between H. pylori infection and gastric MALT lymphoma.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1995
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Molecular analysis of the progression from Helicobacter pylori-associated chronic gastritis to mucosa-associated lymphoid-tissue lymphoma of the stomach
Article Abstract:
The polymerase chain reaction can detect the presence of monoclonal B cells in patients with gastritis, indicating that they may be at risk of lymphoma. Researchers used the technique to analyze biopsy samples from two patients with Helicobacter pylori-associated gastritis, which is an inflammation of the stomach. Both patients were initially diagnosed with gastritis but developed lymphoma later. PCR analysis of biopsy samples taken at both diagnoses revealed the presence of monoclonal B cells before the development of lymphoma. These patients could be treated with antibiotics to eradicate Helicobacter pylori, and hopefully prevent the lymphoma.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
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Disappearance of Hyperplastic Polyps in the Stomach after Eradication of Helicobacter pylori
Article Abstract:
Antibiotic and acid-suppression therapy to eradicate Helicobacter (H.) pylori colonization in the stomach may effectively treat overgrown gastric polyps. H. pylori is a bacterium strongly associated with stomach ulcers. Researchers compared an anti-H. pylori drug combination, or no treatment, in 35 patients with the growths in their stomachs. Polyps disappeared in 3-15 months in 71% of treated patients, but did not change in patients who received no treatment. Successful drug therapy may prevent invasive endoscopic polyp removal in some patients.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1998
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