HIV and malignancy
Article Abstract:
Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma (NHL) are the two types of cancer most prevalent among HIV patients in Australia. KS is characterized by bluish-red nodules on the skin, and research indicates a sexually transmitted agent other than HIV may be responsible for its high incidence among homosexual and bisexual men. Radiotherapy and single or combination chemotherapy are the primary means of treating KS. Researchers are looking into therapies that inhibit KS cell growth factors. NHL occurs in all HIV-infected populations, and its incidence is on the rise. In Australia, 73% of HIV-related NHL cases affect sites outside of the lymph nodes, especially the central nervous system, the gastrointestinal tract and the liver. Only 1/3 of NHL cases have been detected using lymph node biopsies, indicating the need to develop new methods of diagnosing HIV-related NHL. Use of chemotherapy to treat NHL has produced poor results. As therapy for HIV infection improves, the onset of secondary KS and NHL may prove to be a limiting factor in the survival of HIV patients.
Publication Name: Journal of Acquired Immune Deficiency Syndromes
Subject: Health
ISSN: 0894-9255
Year: 1993
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HIV-1-related neurological disease
Article Abstract:
Neurological disorders including AIDS dementia complex (ADC), HIV-1 related myelopathy, neuropathy and myopathy are frequent complications of HIV infection. The incidence of these neurological disorders reflects the stage of HIV infection in the patient. ADC affects individuals late in HIV infection and is characterized by slow intellectual processing, poor attention, clumsiness and poor balance. It affects between 40% and 90% of AIDS patients. HIV-1 related myelopathy affects the spinal cord and often exists in patients with ADC. Peripheral neuropathies are common and can occur at all stages of HIV infection. Painful neuropathies may result from taking the drugs ddI or ddC but usually recede after doses are lowered or ceased. Zidovudine-related myopathy is the most common of the HIV-related myopathies. It usually develops after a year of taking the drug and is characterized by wasting of the buttock muscles and leg weakness.
Publication Name: Journal of Acquired Immune Deficiency Syndromes
Subject: Health
ISSN: 0894-9255
Year: 1993
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